Figure 1.

Time course of disease

A 71-year-old individual without significant past medical history living in an endemic area in southern Germany developed unspecific symptoms of BoDV-1 infection 2 weeks prior to hospitalization. The x axis shows days after hospital admission. Leucocyte count (cells/μL) in cerebrospinal fluid (CSF) is represented on the left y axis, and RNA copies (copies/mL) in CSF obtained through qRT-PCR of two target regions are represented on the right y axis. The diagnosis was made by qRT-PCR from CSF on day 12. Workup of other infectious or autoimmune causes of encephalitis remained negative. The individual died on day 15 after admission.