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. 2022 Jan 10;12:792263. doi: 10.3389/fphar.2021.792263

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Copyright © 2022 Wu, Liang, Xie, Huang, Fu, Wang, Su, Wang, Qu, Li and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Col003 on P-selectin expression and ROS generation induced by collagen in rat platelets. (Ai) Representative scatterplots of P-selectin expression in IgG (negative control), vehicle, and Col003-treated platelets (Aii) The percentage of P-selectin–positive platelets were quantified. The %P-selectin–positive platelets in three different groups were 25.73 ± 0.35% (IgG), 58.43 ± 0.50% (Vehicle), 42.83 ± 1.49% (Col003), respectively. (Bi) Flow cytometry of DCHF-DA–loaded platelets in washed platelets treated with either vehicle or Col003 showing collagen-induced ROS generation. (Bii) The percentage of DCF-positive platelets was quantified. The %DCF-positive events in different three groups were 19.30 ± 1.31% (Resting), 51.08 ± 1.74% (Vehicle), 25.60 ± 3.85% (Col003 50uM), respectively. Statistical analysis was performed with unpaired two-tailed Student’s t-test (**p < 0.01 and ***p < 0.001).