Table 2.

Functional connectivity alterations in the left DLPFC between patients with PD-pRBD⁺ and PD-pRBD⁻ over time.

Anatomical regions	Cluster size (voxel)	MNI (x, y, z)	T-value
T0: PD-pRBD+ vs. PD-pRBD−
Rt.Fp2	54	(0, 66, 0)	−4.26
Lt.hOc4la	78	(−42, −90, −9)	−4.33
Rt.hOc4la	135	(45, −78, −15)	−4.22
T1: PD–pRBD+ vs. PD-pRBD−
N/A	N/A	N/A	N/A
T2: PD-pRBD+ vs. PD–pRBD−
Rt.Fp1	29	(30, 60, −3)	−4.35
Rt.IPS	91	(51, −33, 36)	−5.18

The results were thresholded based on an uncorrected voxelwise height threshold of p < 0.001 combined with an FWE–corrected clusterwise threshold of p < 0.05. PD-pRBD⁺, Parkinson's disease (PD) with probable rapid eye movement (REM) sleep behavior disorder (pRBD); PD-pRBD⁻, PD without pRBD; DLPFC, dorsolateral prefrontal cortex; Fp1, lateral frontopolar area 1; Fp2, medial frontopolar area 2; hOc4la, anterior third of the middle and inferior lateral occipital gyri; IPS, intraparietal sulcus; T0, fMRI data at onset; T1, the 1-year follow-up evaluation; T2, the 3-year follow-up evaluation; Lt, left; Rt, right; N/A, Not Applicable.