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. 2022 Jan 18;3(1):100492. doi: 10.1016/j.xcrm.2021.100492

Figure 4.

Figure 4

Different kinase pathways show distinct mRNA signatures when inhibited

(A and B) Across all models, tyrosine kinase (TK)-targeting drugs performed the best.

(C) Distribution of kinases profiled across the Human Kinome annotated by kinase group.

(D) Correlation of kinase-binding data with transcriptional program.

(E and F) KEGG pathway transformation of kinase space from (C) revealed pathway-specific transcriptional signatures