Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 10;12:808047. doi: 10.3389/fimmu.2021.808047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Murin, Gilchuk, Crowe and Ward

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ebolavirus GP functional and antigenic domain structure. (A) Full-length EBOV GP gene schematic indicating domains determined from structural analysis by color. Residues encompassing each domain are indicated by numbers. The 1-33 dotted domain is the non-structural signal peptide. Residues 313-464 are the mucin-like domain (MLD), which is disordered. The purple region from residues 190-214 represents the cathepsin cleavage loop, which hangs over the internal fusion loop (IFL) and is loosely ordered. (B) Surface rendering of EBOV GP (PDBID: 5JQ3) with corresponding domains shown in ribbon [based on numbering in part A, from Lee et al. (41)]. Antigenic sub-domains are indicated in bullet points. NPC1, Nieman Pick C1; MPER, membrane-proximal external region; TM, transmembrane domain. The structure of the MPER/TM is from PDBID: 5T42.