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. 2022 Jan 10;12:808047. doi: 10.3389/fimmu.2021.808047

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Copyright © 2022 Murin, Gilchuk, Crowe and Ward

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The head domain and NPC1 binding site. (A) The head domain on GP sits below the glycan cap. Antibody Fabs of REGN-3471 (left, blue, EMD: 7902) and mAb114 (right, HC in blue and LC in cyan, PDBID: 5FHC) from two FDA-approved EBOV therapeutics access the head domain through very steep angles. (B) The NPC1 binding site (pink) necessary for viral entry lies within the head domain (blue). NPC1 binds to this region through its Loop C domain (turquoise), which is partially mimicked and blocked by the CDR loops of mAb114 (yellow).