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. 2022 Jan 10;12:808047. doi: 10.3389/fimmu.2021.808047

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Copyright © 2022 Murin, Gilchuk, Crowe and Ward

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The GP2 N-terminus. The N-terminus of GP2 (red) lies at the interface of GP1 (light gray) and GP2 (dark gray), forming during viral spike processing after furin cleavage, generating GP1 and GP2. This region is a hotspot for neutralizing antibodies, such as KZ52 (left, PDBID: 3CSY), 4G7 (middle, PDBID: 5KEN), and 2G4 (right, PDBID: 5KEL) that access this region in nearly identical ways. A limitation for mAbs binding to this domain is that residues in this region are not well-conserved, and thus mAbs to this site are typically single-virus-species specific.