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. 2022 Jan 10;12:808047. doi: 10.3389/fimmu.2021.808047

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Copyright © 2022 Murin, Gilchuk, Crowe and Ward

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The HR2 domain. (B) The HR2 domain (far left in green) lies at the very base of GP, above the membrane proximal external regions that sit directly above the viral envelope and transmembrane domains. ADI-16061 (left, EMD-8698), ADI-15758 (middle, EMD-6588), and BDBV223 (right, composite of PDBID: 6N7J and PDBID: 5JQ3) bind to overlapping epitopes within the HR2 regions, which lies far below the base of GP. Negative stain EM for each of these antibodies indicates that three Fabs can bind simultaneously to a viral spike. (A) Sequence alignment of the HR2 region from all known ebolaviruses demonstrating the high level of sequence conservation in this region. The BDBV223 peptide is highlighted in green.