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Schematic representation of alignment of pestivirus Erns with RNase Rh, which indicates the modular organization of Erns. Erns consists of an RNase domain (dotted) and a C-terminal membrane active domain (black). The C-terminal domain (residues 191 to 227) is used as the antigen in the developed ELISA. Checkered boxes, strongly homologous RNase active-site domains; ellipses, potential glycosylation sites.
