TABLE 3.
Comparison of (R)-4-aminopentanoic acid synthesis results reported in the literaturea.
| Entry | Reaction substrate | Reaction conditions | Time | Conversion rates (%) | Optical purity | Ref |
|---|---|---|---|---|---|---|
| 1 | α,β-unsaturated γ-amino ester (4.5 mmol) | HCONH4/Pd (H2; MeOH, heating) | — | 81 | 72% ee | Palacios et al. (2001) |
| 2 | LA (8 mmol) + FA + ammonia | Au/ZrO2-VS (N2, 5 atm; 130°C) | 16 h | 90 | Racemic | Du et al. (2011) |
| 3 | LA (2 mmol) + FAM | FA (160°C) | 1.5 h | >93 | Racemic | Wu et al. (2019) |
| 4 | LA (1 mmol) + NH3 (gas, 0.5 Mpa) | Pt/P-TiO2 (H2, 1.5 Mpa; MeOH) | 72 h | >89 | Racemic | Xie et al. (2019) |
| 5 | LA (0.01–0.05 mmol) + (R)-α-MBA | (R)-AT (30°C; 160 rpm) | 12–16 h | — | >99% ee | Jiang et al. (2015) |
| 6 | LA (4 mmol) + AF + NADP+ | EcGDHK116Q/N348M, BsFDH (45°C; 200 rpm) | 11 h | >97 | >99% ee | This study |
a
Abbreviations used: FA, Formic acid; FAM, formamide; MeOH, Methyl alcohol; (R)-AT, (R)-selective amine transaminase; (R)-α-MBA, (R)-1-methylbenzylamine; AF, Ammonium formate.