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. 2022 Jan 10;12:804387. doi: 10.3389/fimmu.2021.804387

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Copyright © 2022 Huang, Liang, Zhang, Tian, Cong, Wu, Zhang, Gao, Li, Chen, Zhang, Dong, Wan, He, Dai, Li and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The roles of SARS-CoV-2-required genes in SARS-CoV-2 infection processes and influence of host genetic factor in COVID-19 outcomes. (A) The vital host genes required for SARS-CoV-2 infection processes containing initial binding, endosomal entry, spike protein cleavage, and viral membrane fusion, endosome recycling, ER-Golgi trafficking, and transcriptional modulators. (B) SARS-COV-2-infected patients with risk genotypes appear more vulnerable to SARS-COV-2 infection and poor outcome, while those carrying protective genotypes appear more vulnerable to lower SARS-COV-2 possibility and good outcome^5-9. This figure is drawn on the Biorender website at https://biorender.com/.