Table 1.
Patient Characteristics
| Lipoprotein(a) ≥70 mg/dL (n = 43) | Lipoprotein(a) <70 mg/dL (n = 148) | P Value | |
|---|---|---|---|
| Baseline | |||
| Lipoprotein(a), mg/dL | 100 (82–115) | 10 (5–24) | |
| Clinical | |||
| Age, y | 65.0 ± 7.1 | 65.3 ± 8.7 | 0.864 |
| Male | 31 (72.1) | 122 (82.2) | 0.217 |
| Body mass index, kg/m2 | 29.1 ± 5.0 | 30.0 ± 5.2 | 0.342 |
| Systolic blood pressure, mm Hg | 141 ± 18 | 148 ± 20 | 0.035 |
| Diastolic blood pressure, mm Hg | 78 ± 9 | 82 ± 11 | 0.033 |
| Active smoking | 5 (11.6) | 23 (15.6) | 0.682 |
| Diabetes mellitus | 5 (11.6) | 31 (21.1) | 0.242 |
| Total cholesterol, mmol/L | 4.27 ± 0.86 | 4.18 ± 1.00 | 0.545 |
| Low-density lipoprotein cholesterol, mmol/L | 2.36 ± 0.62 | 2.22 ± 0.81 | 0.270 |
| High-density lipoprotein cholesterol, mmol/L | 1.27 ± 0.39 | 1.11 ± 0.28 | 0.003 |
| Triglycerides, mmol/L | 1.20 (0.90–1.70) | 1.65 (1.20–2.30) | 0.002 |
| Creatinine, μmol/L | 77 ± 10 | 82 ± 17 | 0.066 |
| Statin use | 43 (100) | 137 (93.2) | 0.171 |
| Antiplatelet therapy | 40 (93) | 143 (97.3) | 0.399 |
| ASSIGN score | 20.6 (10.1) | 27.7 (16.0) | 0.006 |
| Acute coronary syndrome | 32 (74.4) | 105 (70.9) | 0.848 |
| Percutaneous coronary intervention | 36 (83.7) | 112 (76.2) | 0.402 |
| Coronary artery bypass graft | 9 (20.9) | 25 (17.0) | 0.716 |
| Imaging measurements | |||
| Vessel involvement | 0.396 | ||
| 0 | 3 (7.0) | 6 (4.1) | |
| 1 | 8 (18.6) | 43 (29.3) | |
| 2 | 20 (46.5) | 64 (43.5) | |
| 3 | 12 (27.9) | 30 (20.4) | |
| 4 | 0 (0) | 4 (2.7) | |
| Coronary segment involvement score | 5.1 (2.3) | 5.6 (2.3) | 0.192 |
| Coronary calcium score (Agatston units) | 378 (137–650) | 371 (101–894) | 0.902 |
| Total plaque burden, % | 57 (54–67) | 58 (53–66) | 0.531 |
| Calcific plaque burden, % | 3.6 (2.2–10.7) | 3.9 (1.5–8.5) | 0.644 |
| Noncalcific plaque burden, % | 53.7 (50.3–60.2) | 53.9 (49.6–58.0) | 0.584 |
| Low-density plaque burden, % | 3.7 (2.1–5.7) | 3.8 (2.3–6.5) | 0.848 |
| Fibro-fatty plaque burden, % | 20.5 (16.0–30.4) | 24.3 (16.6–28.8) | 0.578 |
| Total plaque volume, mm3 | 1,452 (1,043–1,963) | 1,351 (1,061–1,994) | 0.997 |
| Calcific plaque volume, mm3 | 98 (38–205) | 94 (32–231) | 0.857 |
| Noncalcific plaque volume, mm3 | 1,290 (959–1,668) | 1,282 (977–1,718) | 0.958 |
| Low-density plaque volume, mm3 | 87 (46–144) | 87.09 (50–174) | 0.742 |
| Fibro-fatty volume, mm3 | 471 (329–388) | 571 (313–836) | 0.864 |
Values are mean ± SD, median (IQR), or n (%). BoldP values <0.05 show statistically significant differences.