Fig. 1.

Participant inclusion diagram. Notes: Eight exclusion categories are shown with the corresponding numbers of participants per category. On removal of duplicates a total of 154902 unique participants were considered ineligible for analysis. a) admissions prior to study start date, post death/censoring date or registered death prior to study start; b) individuals that have a mismatch between genetically inferred and reported gender, individuals with sex chromosome types putatively different from XX or XY and individuals that are outliers in heterozygosity and missing rate; c) individuals related to more than 200 other participants; d) on exclusion a maximal set of unrelated individuals is retained; e) not genotyped for the exposures of interest (BMI, WHR, WHRadjBMI).