Table 5.
Association between weighted GRSs for BMI, WHR and WHRadjBMI with BMI and WHR in UK Biobank participants of White British ancestry (N = 310,471). Effect estimates are provided per unit (BMI) and per 0.1 unit (WHR).
| Effect estimate (95% CI)a | P-value | R2% | F | |
|---|---|---|---|---|
| BMI GRS (76 SNPs) | ||||
| BMI (unit) | 0.112 (0.109 – 0.115) | < 5 × 10-324 | 1.69 | 5326 |
| WHR (0.1 unit) | 0.0075 (0.0069 – 0.0081) | < 4.04 × 10-144 | 0.210 | 654.1 |
| WHR GRS (39 SNPs) | ||||
| BMI (unit) | 0.0297 (0.0256–0.0337) | < 2.33 × 10-46 | 0.066 | 204.4 |
| WHR (0.1 unit) | 0.0140 (0.0132 – 0.0148) | < 6.40 × 10-277 | 0.406 | 1267 |
| WHRadjBMI GRS (48 SNPs) | ||||
| BMI (unit) | -0.024 (−0.0278 to −0.0202) | < 2.41 × 10-35 | 0.050 | 154 |
| WHR (0.1 unit) | 0.0141 (0.0134 – 0.0148) | < 1.88 × 10-322 | 0.474 | 1477 |
BMI = body mass index, CI = confidence interval, GRS = genetic risk score, SD = standard deviation, WHR = waist hip ratio, WHRadjBMI = waist hip ratio adjusted for BMI
a) Effect estimate, and corresponding P-value represent the change in BMI in units (kg/m2) and the change in WHR in 0.1 units per BMI increasing allele (BMI GRS) and WHR increasing allele (WHR GRS, WHRadjBMI GRS). Effect estimates per BMI and WHR SD are given in Table S4.
b) R2 values are given in % (e.g., 1.69 here indicates an R2 of 0.0169)