Table 7.
One-sample MR analyses of the effect of BMI (76 SNPs), WHR (39 SNPs) WHRadjBMI (48 SNPs) on yearly hospital admission rate per year in UK Biobank participants of White British ancestry (N = 310,471), per sex (female, N = 166,610; male, N = 143,861). Rates and 95% confidence intervals (95% CI) are given. Estimates are provided per exposure SD, with in the female subset SDBMI= 5.12 and SDWHR= 0.070, and in the male subset SDBMI= 4.22 and SDWHR= 0.065.
|
Female |
Male |
|||
|---|---|---|---|---|
| Observational (adjusteda) | IV (adjustedb) | Observational (adjusteda) | IV (adjustedb) | |
| Ratec 95%CI | Ratec 95%CI | Ratec 95%CI | Ratec 95%CI | |
| BMI (SD) | 1.078 (1.061–1.095) | 1.108 (0.951–1.292) | 1.076 (1.057–1.108) | 1.162 (0.999–1.352) |
| WHR (SD) | 1.112 (1.094–1.13) | 1.032 (0.859–1.241) | 1.128 (1.108–1.150) | 1.597 (1.105–2.309) |
| WHRadjBMI (SD) | 1.094 (1.074–1.113) | 1.062 (0.925–1.219) | 1.122 (1.096–1.148) | 1.499 (1.035–2.173) |
BMI = body mass index, CI = confidence interval, IV = instrumental variable, SD = standard deviation, WHR =waist hip ratio, WHRadjBMI = waist hip ratio adjusted for BMI
a) Adjusted for age at study entry, alcohol frequency (categorical, from on a daily basis to never), employment (categorical), qualifications (categorical), Townsend deprivation score (categorical in quintiles, where 1 is not deprived and 5 is very deprived), and days of exercise per week (categorical, from 1 to 7);
b) Adjusted for age at study entry and 40 PCAs
c) Estimates (with corresponding 95% CIs) represent the fold increase in yearly hospital admission rate per BMI SD (5.12 kg/m2 and 4.22 kg/m2, for female and male, respectively) and per WHR SD (0.070 and 0.065, for female and male, respectively). Estimates per BMI and WHR unit are given in Table S6.