Fig. 5.

Summary of myopathogenes associated with satellite cell function. Heatmap depicting the characteristics of the 63 myopathogenes associated with satellite cells. A. Mutation in specific neuromuscular disease class/es [15]. B. Differential expression during early satellite cell (SC) activation in mouse [168]. C. Binding by Pax7 in chromatin immunoprecipitation (ChIP) in mouse myoblasts [169]. D. Differential regulation in response to Pax7 overexpression (o/e) in mouse myoblasts ([169]; LogFold Change≥ 0.5 or ≤ −0.5). E. Expression in PAX7-positive, PAX7-negative or PAX7-null human satellite cells ([24] reported as low, medium or high, based on counts per million (cpm). F. Effect of the myopathogene mutation on the number of satellite cells in patients with citation. G. Effect of the myopathogene mutation on satellite cells in in vivo/vitro models with citation. Sample type and species source of data from human, mouse or cultured cells are depicted by icons in the key.