Table 1.
IL-6 pathway inhibitors
| Drug | Mechanism of action | Indications |
|---|---|---|
| Siltuximab | IL-6 inhibitor | Multicentric Castleman disease |
| Tocilizumab | IL-6R inhibitor |
Giant cell arteritis Juvenile rheumatoid arthritis Rheumatoid arthritis Cytokine release syndrome |
| Sarilumab | IL-6R inhibitor | Rheumatoid arthritis |
| Ruxolitinib | JANUS-associated protein kinase (JAK1 and JAK2) inhibitor |
Myelofibrosis Polycythaemia vera |
| Baricitinib | JANUS-associated protein kinase (JAK1 y JAK2, TyK2) inhibitor | Rheumatoid arthritis |