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. 2022 Jan 10;11:798296. doi: 10.3389/fonc.2021.798296

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Copyright © 2022 Kulasinghe, Monkman, Shah, Matigian, Adams and O’Byrne

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential protein expression comparing relapse and complete response. (A) Upper panel. Volcano scatter plot showing stromal enrichment of log2 fold change in proteins from responders (left half) vs non-responders (right half) ranked by significance (-log₁₀ P value). Lower panel. List of top three significant deregulated proteins ranked by P value. (B) Boxplots indicating enrichment of 41BB and ERα in non-responders and responders, respectively. (C) Upper panel. Volcano scatter plot showing tumour region enrichment of log2 fold change in proteins from responders (left half) vs non-responders (right half) ranked by significance (-log₁₀ P value). Lower panel. List of top four significant deregulated proteins ranked by P value. (D) Boxplots indicating enrichment of CD80 and GZMA in non-responders and responders, respectively.