TABLE 1.

Shared genetic variants between lymphangioleiomyomatosis (LAM) and cancer risk (ordered by cancer type)

Cancer type	SNP	Chr	Position (bp, hg19)	Reference allele	Alternative allele (MAF)	C ancer p-value	LAM p-value	Cancer Z score	LAM Z score	Pleiotropy	conjFDR	Locus
Gastric	rs3861451	6	148 320 047	T	C (0.33)	1.6×10−4	1.2×10−5	3.78	−4.38	Antagonist	0.022	Intergenic
	rs9528802	13	65 235 556	T	C (0.29)	1.8×10−4	2.4×10−4	3.74	3.68	Agonist	0.035	Intergenic
	rs10901587	10	128 001 759	C	T (0.23)	2.5×10−4	2.5×10−4	3.67	3.66	Agonist	0.037	ADAM12 intronic
Kidney	rs4512050	4	158 597 491	A	G (0.13)	2.9×10−4	1.9×10−4	3.62	3.74	Agonist	0.044	Intergenic
	rs17036640		158 605 184	A	G (0.13)	2.5×10−4	1.7×10−4	3.67	3.76	Agonist	0.037	Intergenic
	rs2146084	9	11 2505 617	G	A (0.12)	2.6×10−5	2.7×10−4	−4.21	3.65	Antagonist	0.047	PALM2-AKAP2 intronic
Prostate	rs4668267	2	171 360 896	T	C (0.30)	7.9×10−5	8.7×10−5	3.95	3.93	Agonist	0.030	MYO3B intronic

SNP: single nucleotide polymorphism; Chr: chromosome; MAF: minor allele frequency; conjFDR: conjunctional false discover rate.