Table 2.

Assessment questions for the uncertainty analysis on hazard identification and characterisation

Line of evidence	Question 1. Hazard identification	Question 2. Hazard characterisation	Answer
In vitro experimental studies	Is the measured endpoint affected in a concentration‐response relationship in the evaluated study?	What is the lowest concentration at which exposure affects the endpoint?	(Q1. Yes/No + Q2. Lowest concentration/dose) + summary of the uncertainties for the assessment endpoint category
In vivo experimental studies	Is the measured endpoint affected in a dose–response relationship in the evaluated study?	What is the lowest dose at which exposure affects the endpoint?