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. 2021 Sep 13;93(2):201–206. doi: 10.1136/jnnp-2021-327520

Figure 1.

Figure 1

(A) Pedigree of Family D where only the youngest member in generation II has developed ALS. He tested positive for heterozygosity for the p.Asp102Asn SOD1 mutation. The parents are in their late 60s and early 70s, respectively. Open symbols, unaffected family members. (B) Abbreviated pedigree of Family E. The family comes from an area where extensive ALS research has been performed for decades but only two the father (IV-6) and son (V-4) with ALS could be found in the extended family. V-4 tested positive for heterozygosity for the p.Asp102Gly SOD1 mutation. Ages at death (per decade) are listed below each individual. Changes have been made to the pedigree for anonymisation purposes. ALS, amyotrophic lateral sclerosis; Wt, wild type SOD1 allele.