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. 2021 Nov 11;93(2):216–219. doi: 10.1136/jnnp-2021-327468

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Box-and-Whisker plots of (A) the inter-eye percentage differences (IEPD) and (B) the inter-eye absolute difference (IEAD) at baseline, year 2 and year 4. The red line indicates the 5% cut-off for the IEPD and the 4 µm cut-off of the IEAD. BON, bilateral MS associated optic neuritis; HC, healthy controls; MS, multiple sclerosis; NON, no MS associated optic neuritis; ON, unilateral MS associated optic neuritis. The median (bold horizontal line), 25–75 percentiles (box), 5–95 percentiles (whiskers), mean (symbol in the box) and outliers (symbols outside the box) are shown.