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. 2021 Sep 28;93(2):169–179. doi: 10.1136/jnnp-2021-326630

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Whole brain, grey matter and white matter changes in patients with Parkinson’s disease (PD) and visual hallucinations (VH) at 18 months follow-up. (A) Changes in cortical thickness seen in patients with compared with those without hallucinations (PD non-VH) at 18 months follow-up, on a surface rendered right hemisphere (left: lateral view top panel, medial view bottom panel) and left hemisphere. No statistically significant changes were seen in cortical thickness at baseline imaging. Colour coding indicates cluster significance for group-by-time interactions. Significance levels are on a logarithmic scale of p values (−log10). Positive values indicate PD-VH cortical thickness <PD non-VH; negative values indicate PD-VH >PD non VH. Results are corrected for false discovery rate across both hemispheres. (B) Changes in white matter macrostructure (fibre cross-section, FC) seen in PD-VH compared with PD non-VH at longitudinal follow-up. Baseline changes are presented in online supplemental figure 1. Results are displayed as streamlines; these correspond to fixels that significantly differed between PD low and high visual performers (family-wise error correction (FWE)-corrected p<0.05). Streamlines are coloured by percentage reduction (colourbars) in PD-VH compared with PD non-VH.