Table 5.

Neuroimaging Measures and suggested sequences

Domains	Measures	Sequences
Structural Neuroimaging	T1-Weighted	176 slices, voxel size = 1.0x1.0x1.0, TR = 2300 msec, TE = 2.98 msec, FoV of 256 mm
	3D fluid attenuated inversion recovery	176 slices, voxel size = 1.0x1.0x1.0, TR = 6000 msec, TE = 390 msec, FoV of 256 mm
	Diffusion Tensor Imaging	64 directions, 59 slices, voxel size = 2.7x2.7x2.7, TR = 9000 msec, TE = 94 msec, FoV of 350 mm
	3D Susceptibility Weighted Imaging	128 slices, voxel size = 1.3x1.3x1.3, TR = 45 msec, TE = 25 msec, FoV of 256 mm
Functional Neuroimaging	Resting State Functional MRI	48 slices, voxel size = 3.3x3.3x3.3, TR = 3000 msec, TE = 30 msec, FoV of 212 mm. Minimum 6-min sequence with eyes open.
Metabolic Neuroimaging	Magnetic Resonance Spectroscopy (MRS)*	PRESS voxel imaging: (TE = 30 ms, TR = 2000 ms, voxel size 20x20x20mm, 128 averages, water reference).
		Semi-LASER chemical shift imaging: (TE = 30 ms, TR = 1500 ms, voxel size 10x10x15mm, FoV 160 mm, 16 × 16).

^*Collection of T1-Weighted sequences is required for MRS. PRESS single voxel should be acquired in the anterior and posterior cingulate and parietal white matter and chemical shift imaging as a slab across the corpus callosum localized on the MPRAGE or FLAIR images