Table 2.

Chromosomal aberrations in bone marrow cells of male BALB/c mice treated with Fe₂O₃, Al₂O₃ and Cu nanoparticles

Group	Dose (mg/kg)	No. of analysed metaphases	Chromosomal aberrations				TA/500 cells	CA/cell Mean ± SD
			CtB	ChB	CtG	ChG
Fe2O3 nanoparticles
NC	0	500	18	13	14	15	60	0.120±0.026
PC	2	500	106	35	104	60	305	0.610±0.081*
1	75	500	21	10	35	15	89	0.178±0.057
2	150	500	20	12	38	10	86	0.172±0.023
3	300	500	27	09	40	16	92	0.184±0.029
Al2O3 nanoparticles
NC	0	500	14	16	11	17	58	0.116±0.019
PC	2	500	102	41	115	53	311	0.622±0.147*
1	75	500	20	13	38	12	83	0.166±0.081
2	150	500	15	10	43	10	79	0.158±0.046
3	300	500	19	14	40	11	89	0.168±0.039
Cu nanoparticles
NC	0	500	15	12	18	16	61	0.12 ±0.037
PC	2	500	98	35	110	61	304	0.608±0.081*
1	5	500	20	13	22	15	70	0.140±0.054
2	10	500	19	14	20	16	69	0.138±0.048
3	15	500	50	26	68	41	185	0.370±0.076*

^*Data are expressed as means ± SD (n=5).

^*significant difference from negative control (P<0.05); NC – negative control; PC – positive control (single ip dose of 2 mg/kg mitomycin C); TA – total number of aberrant cells; CtB – chromatid breaks; ChB – chromosome breaks; CtG – chromatid gaps; ChG – chromosome gaps