Table 2.
Univariable and multivariable Cox regression analysis for survival in IDH-mut lower grade astrocytomas (1p19q-noncodel) and oligodendrogliomas (1p19q-codel) without known CDKN2A/B homozygous deletion, n=157.
| Variable | Univariable HR (95% CI) | p-value | Multivariable HR (95% CI) | p-value |
|---|---|---|---|---|
| Male sex (ref female) | ||||
| Astrocytoma | 1.35 (0.70–2.59) | 0.38 | ||
| Oligodendroglioma | 0.58 (0.17–1.97) | 0.38 | ||
| Age (years) | ||||
| Astrocytoma | 1.03 (1.00–1.05) | 0.038 | 1.01 (0.98–1.04 | 0.64 |
| Oligodendroglioma | 1.06 (1.01–1.10) | 0.025 | 1.05 (1.00–1.10) | 0.079 |
| Asymptomatic (ref symptomatic) | ||||
| Astrocytoma | 1.44 (0.34–6.00) | 0.62 | ||
| Oligodendroglioma | 0.48 (0.06–4.11) | 0.50 | ||
| KPS score 80 or below (ref KPS 90-100) | ||||
| Astrocytoma | 1.92 (1.02–3.63) | 0.044 | 1.79 (0.83–3.84) | 0.14 |
| Oligodendroglioma | 1.45 (0.42–4.97) | 0.56 | ||
| Max tumor diameter (mm) | ||||
| Astrocytoma | 1.04 (1.02–1.05) | <0.00001 | ||
| Oligodendroglioma | 1.05 (1.02–1.08) | 0.001 | 1.05 (1.01–1.09) | 0.01 |
| Tumor location non-frontal (ref frontal) | ||||
| Astrocytoma | 1.87 (0.63–2.23) | 0.60 | ||
| Oligodendroglioma | 0.35 (0.04–2.72) | 0.31 | ||
| Eloquence (Chang) (ref non-eloquent) | ||||
| Astrocytoma | 2.87 (1.12–7.36) | 0.028 | 1.72 (0.62–4.74) | .30 |
| Oligodendroglioma | 0.44 (0.13–1.56) | 0.21 | ||
| Bilateral growth (ref unilateral) | ||||
| Astrocytoma | 2.56 (1.06–6.17) | 0.037 | 0.42 (0.09–1.88) | .26 |
| Oligodendroglioma | 2.09 (0.44–10.01) | 0.38 | ||
| Lack of tumor border (ref detectable tumor border) | ||||
| Astrocytoma | 4.48 (1.99–10.11) | <0.001 | 1.33 (0.33–5.39) | .69 |
| Oligodendroglioma | 2.64 (0.68–10.29) | 0.16 | ||
| Contrast enhancement (ref no enhancement) | ||||
| Astrocytoma | 1.51 (0.79–2.87) | 0.21 | ||
| Oligodendroglioma | 1.22 (0.34–4.37) | 0.76 | ||
| Focal deficit (ref no focal deficit) | ||||
| Astrocytoma | 1.72 (0.78–3.77) | .18 | ||
| Oligodendroglioma | 6.48 (1.54–27.34) | .01 | 2.21 (0.49–10.11) | .30 |
| Grade 3 (ref grade 2) | ||||
| Astrocytoma | 0.95 (0.50–1.79) | 0.87 | ||
| Oligodendroglioma | 0.91 (0.28–2.99) | 0.88 | ||
| Early postop radio-chemotherapy (within 6 months) (ref no early R-C-therapy) | ||||
| Astrocytoma | 0.77 (0.39–1.51) | 0.44 | ||
| Oligodendroglioma | 0.32 (0.04–2.50) | 0.28 | ||
| Residual tumor volume above 10 ml (ref volume ≤ 10 ml) | ||||
| Astrocytoma | 5.90 (2.69–12.92) | <0.00001 | [6.30 (2.22–17.86)]* | (0.001)* |
| Oligodendroglioma | 1.60 (0.43–5.98) | 0.48 | ||
| Residual tumor volume (ml) | ||||
| Astrocytoma | 1.02 (1.01–1.03) | <0.000001 | 1.02 (1.01–1.03) | 0.003 |
| Oligodendroglioma | 1.01 (1.00–1.03) | 0.085 |
KPS denotes Karnofsky Performance Status.
*Results from a separate multivariable analysis where the continuous variable of residual tumor volume is replaced by a dichotomized counterpart. Two additional multivariable models are presented in the text but not shown in this table for clarity.
Bold text indicates p-value < 0.05.