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. 2022 Jan 19;8:20595131211038313. doi: 10.1177/20595131211038313

Table 5.

Clinical evidence for ADM in andrology.

Authors Product name(s), Material Usage, Population Summary findings
Retrospective studies
Xu et al. (2019) Unspecified PADM Penile girth enhancement
78 patients
Mean age: 31.14 years (age range = 21–66 years)
Exclusion: patients aged 70+ years, history of mental illness, coagulopathy or type I/II diabetes
  • 3-month postoperatively: penile circumference increased by 1.1 cm (range = 0.5–2.1 cm) on average

  • Complications noted: 47 patients with erectile discomfort, 12 patients delayed healing, 10 unobvious augmentation effect, 8 wound haematoma, 7 prepuce oedema, 4 wound infection and 3 with skin necrosis of the dorsal side

  • 7 patients eventually underwent ADM removal

Prospective studies
Alei et al. (2012) Unspecified PADM Penile girth augmentation
69 patients
  • Postoperatively at 6 and 12 months: mean flaccid penis circumference was 11.3 cm (range = 8.2–13.2 cm), a 3.1-cm mean increase, and erect mean circumference was 13.2 cm (range = 8.8–14.5 cm), a 2.4-cm increase

  • Psychosexual impact of operation was beneficial in the majority

  • Minor complications resolved with conservative treatment within 3 weeks, no major complications noted

Tealab et al. (2013) Pelvicol™,
PADM
Penile augmentation
18 patients
Mean age: 24 years (age range = 19–38 years)
  • Pelvicol is not an ideal option for enhancing penile girth

  • In total after 1 year: 2 patients highly satisfied, 7 patients moderately satisfied and 9 unsatisfied

  • 8 total complications resulting in severe penile oedema and ischemic shaft ulcers

  • 4 total patients required total graft removal

  • Group 1: mean increase in girth was 2.8 cm (range = 2–3.2 cm); Group 2: mean girth increase was 1.7 cm (range = 1.2–2 cm)

Zhang J et al. (2004) Unspecified PADM Penile augmentation
12 patients
  • Postoperative: mean increase in flaccid penile girth was 2.6 cm (1.3–3.1 cm)

  • All patients regained sexual ability within 3 months postoperatively

  • 1 patient: delayed wound healing (due to tight dressing), repaired with a scrotal skin flap

  • Aesthetically normal results without contour deformities

Zhang X et al. (2018) Unspecified PADM Penile augmentation for improvements in premature ejaculation
39 patients
Mean age at the time of operation: 29 years (age range = 24–37)
Excluded: those with penis deformities, bleeding disorders, keloid formation; those who were on medication for ejaculatory function
  • Baseline data: 6.93 ± 1.00 cm flaccid girth, 10.59 ± 1.15 cm erect girth, 225.6 ± 120.4 s IELT (self-estimated)

  • 6-month follow-up: 8.07 ± 1.06 cm flaccid girth, 12.79 ± 1.22 cm erect girth, 424.3 ± 123.8 s IELT (self-estimated)

  • 2-year follow-up: 7.89 ± 1.04 cm flaccid girth, 11.53 ± 1.19 cm erect girth, 412.8 ± 123.1 s IELT (self-estimated)

  • Minor complications were resolved with conservative treatment within 3 weeks

Zhang Z et al. (2015) Unspecified PADM Wound healing of Fournier gangrene
36 total patients, 17 experimental (those with XADM) and 19 controls
  • Hospitalisation period: experimental group 26.06 ± 0.83 days and control group 38.11 ± 5.60 days

  • Wound preparation time: experimental group 13.64 ± 1.46 days and control group 22.37 ± 1.38 days

  • Interecological organisation protection, granulation tissue growth promotion, and penile function and morphology retained all observed

ADM, acellular dermal matrix; IELT, intravaginal ejaculation latency time; PADM, porcine acellular dermal matrix; XADM, xenographic acellular dermal matrix.