Table 9.

Clinical evidence for ADMs in urology.

Authors	Product name(s), Material	Usage, Population	Summary findings
Case series and case reports
Bonitz et al. (2016)	AlloDerm®, HADM AlloMax®, HADM	CBE 6 male patients, born with CBE, and who had abdominal wall defects. 2 children, aged 6 and 8 years, with unrepaired bladder exstrophy plates and large abdominal wall defects (8 and 12 cm wide). Both had their bladders reconstructed, placed within the pelvis, and HADM was used to replace the absent abdominal wall (bridged repair) without the use of pelvic osteotomy. In 3 other patients, HADM reinforced the native fascial repair (bolster repair). HADM also served as a filler for the abdominal depression that was present after initial staged repair. Where HAD was used for bridged or bolster repair, the edges of the allograft were extended 2–3 cm beyond the perimeter of the defect	Follow-up: 1–3 years All 6 patients healed without evidence of abdominal wall hernias. All regained functional level of abdominal wall strength 2 children successfully underwent a secondary procedure through the bridged allograft repair (both required bladder neck reconstruction and bilateral ureteral reimplantation). Continence was achieved in both, with one voiding at 2-h intervals and the other at 3-h intervals 1 patient developed a urethral-cutaneous fistula, distant to the allograft No associated wound complications

ADM, acellular dermal matrix; CBE, classic bladder exstrophy; HADM, human acellular dermal matrix.