Figure 3.

Illustration of proposed modulation of K⁺ transport. Proteins modulated by DTMP that are involved in K⁺ regulation in postsynaptic neurons and surrounding astrocyte cells. K⁺ leak channels and pumps are important in resetting membrane potential and limiting action potential characteristics. Reduction in K⁺ efflux, induced by the pain model, promotes depolarization and increased hypersensitivity. DTMP reversed changes in K⁺ regulation induced by the pain model. Some proteins that further promote K⁺ regulation, though unaffected by SNI, were also increased following DTMP.