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. 2022 Jan 4;9:738916. doi: 10.3389/fcell.2021.738916

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Copyright © 2022 Cevatemre, Ulukaya, Dere, Dilege and Acilan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDHi treatment resulted in growth inhibition. (A) A549 cells were treated (72 h) with PDHi at indicated doses and after staining with SRB dye, cells were photographed under phase contrast microscope (magnification 100×). (B) The effect of PDHi on the growth of A549 cells was quantified by SRB and ATP viability assays. Data are presented as mean ± SEM. (C) The cell index (CI) values for 0–200 μM (represented by different colours) of PDHi on A549 cells was generated by real time cell analyzer (RTCA). * Significantly difference compared to untreated cells (p < 0.0001).