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. 2022 Jan 4;9:738916. doi: 10.3389/fcell.2021.738916

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Copyright © 2022 Cevatemre, Ulukaya, Dere, Dilege and Acilan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with a TGFβRI inhibitor (SB-431542) reversed PDHi-induced vimentin expression and morphological changes. The cells were co-incubated with 2.5 µM of TGFβRI-i and PDHi for 72 h. (A) Treated cells were analyzed by western blot for the expression levels of Vimentin and β-Actin was used as a loading control. Data are presented as mean ± SEM. *Significantly difference compared to PDHi-alone (***p < 0.0001) (B) Rescue of growth inhibition was analyzed by SRB and ATP viability assays. Data are presented as mean ± SEM. *Significantly difference compared to PDHi-alone (*p < 0.01, ***p < 0.0001). (C) Morphology of PDHi and/or TGFβRI-i treated cells for 72 h and cells were visualized by using the SRB dye (magnification 100×).