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PDHA1 knockdown induced chemoresistance in lung cancer cells. (A) shPDHA1 cells are more chemoresistant than shCtrl cells at individual doses of paclitaxel, docetaxel, pemetrexed, and 5FU, as shown by ATP viability assay. *Significantly difference compared to shCtrl cells (*p < 0.05, **p < 0.001, ***p < 0.0001) (B) p44/42 MAPK (Erk1/2), p38-MAPK, p-c-JUN proteins in shCtrl and shPDHA1 cells were determined by western blotting.
