Skip to main content
. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: Exp Neurol. 2020 Sep 17;334:113465. doi: 10.1016/j.expneurol.2020.113465

Figure 1. Representative data showing the acute impact of intravenous delivery of ampakine CX717 on phrenic motor output, heart rate, and MAP at 8 weeks following C2Hx injury.

Figure 1.

The traces show that infusion of ampakine solution (indicated by the arrow and dashed line) evoked a rapid and bilateral increase in phrenic motor output with relatively little impact on respiratory rate. Panels a and b provide expanded time scale traces which highlight the increase of inspiratory burst amplitude recorded ipsilateral to the C2Hx injury. ABP = arterial blood pressure (ABP); HR = heart rate; ETCO2 = end-tidal CO2; RR = respiratory rate; ʃPhr = integrated phrenic signal; CL = contralateral to C2Hx; IL = ipsilateral to C2Hx. The phrenic nerve burst amplitude can be considered as arbitrary units (au).