Data are shown from 2-weeks post-C2Hx (panels A-C) and 8-wks post-C2Hx (panels D-F). Data were collected in separate cohorts of rats as described in the text. In panel A, ipsilateral phrenic nerve output was absent during baseline recordings in several animals within each group. Thus, for Panel A, n=5 for CX717, n=6 for CX717+hypoxia, and n=6 for HPCD+hypoxia. The sample size is n=8 for all groups in Panels B-F. *, indicates that the CX717+hypoxia data point is statistically greater than baseline; ★, indicates that the CX717 alone data point is statistically greater than baseline. ANOVA results are presented in the main text.