Table 1.
Age, weight, phrenic nerve inspiratory burst ʃamplitude, burst frequency, heart rate, and mean arterial pressure during the baseline recordings. There were no differences in any of these parameters when comparing across treatment groups.
CX717 | CX717 + Hypoxia | HPCD + Hypoxia | |
---|---|---|---|
| |||
Age at experiment (weeks) | |||
2 wk post-Hx | 13.9±1.6 | 13.4±1.4 | 14.0±1.5 |
8 wk post-Hx | 18.6±1.5 | 18.6±1.8 | 18.2±1.7 |
Age at time of surgery (weeks) | |||
2 wk post-Hx | 11.8±1.7 | 11.1±1.3 | 11.8±1.5 |
8 wk post-Hx | 10.4±1.4 | 10.6±1.6 | 10.2±1.6 |
Weeks post injury | |||
2 wk post-Hx | 2.1±0.2 | 2.3±0.4 | 2.3±0.3 |
8 wk post-Hx | 8.2±0.6 | 7.9±0.6 | 8.0±0.5 |
| |||
Weight at experiment (grams) | |||
2 wk post-Hx | 331 ± 32 | 317 ± 34 | 318 ± 28 |
8 wk post-Hx | 393±28 | 409±22 | 392±35 |
Weight at Hx (grams) | |||
2 wk post-Hx | 301±38 | 301±33 | 307±15 |
8 wk post-Hx | 329±37 | 320±20 | 391±33 |
| |||
ʃBurst Amplitude (mV) | |||
Ipsilateral, 2 wk post-Hx | 1.6±1.1 | 1.9±0.1.2+ | 2.5±1.4+ |
Contralateral, 2 wk post-Hx | 9.1±3.3 | 9.1±6.7 | 7.8±2.2 |
Ipsilateral, 8 wk post-Hx | 1.4±0.6 | 2.8±2.1 | 2.0±1.7 |
Contralateral, 8 wk post-Hx | 7.8±2.6 | 8.7±5.3 | 12.0±4.4 |
| |||
Frequency (per minute) | |||
2 wk post-Hx | 52±5 | 52±6 | 50±5 |
8 wk post-Hx | 51±6 | 53±6 | 54±3 |
| |||
Heart Rate (per minute) | |||
2 wk post-Hx | 438±11 | 436±23 | 451±17 |
8 wk post-Hx | 417±21* | 423±14 | 411±14* |
| |||
Mean Arterial Pressure (mmHg) | |||
2 wk post-Hx | 114±9 | 126±20 | 114±15 |
8 wk post-Hx | 141±20* | 145±23 | 141±25* |
Data are presented as Mean ± SD.
different than the corresponding 2-week time point within the treatment group, p<0.05;
does not include experiments were the baseline phrenic burst amplitude was zero