Table 2.

Arterial blood gas values at 2-weeks post-injury. Blood gases were similar between the three treatment groups at baseline. Within each treatment group, values of each parameter were stable and not statistically different across the 90-minute experimental paradigm (with the exception of reduced PaO₂ during hypoxia). PaO₂ values were slightly lower at 20-min following hypoxia as compared to the ampakine alone group which did not have an initial hypoxia bout.

2 weeks post injury	PCO2	PO2	pH
CX717
Baseline	46.1±1.6	316.8±19.6	7.36±0.02
20 min	45.9±1.7	315.1±10.5	7.35±0.01
40 min	46.1±1.5	312.6±19.5	7.36±0.02
60 min	46.8±0.9	317.7±10.3	b7.35±0.02
90 min	46.2±2.1	317.7±7.6	b7.35±0.02
CX717 + Hypoxia
Baseline	45.9±1.4	314.1±14.5	7.37±0.01
Hypoxia 1	45.9±2.8	*48.8±5.9	7.36±0.02
20 min	46.7±1.3	a272.3±34.3	7.37±0.02
40 min	46.1±1.8	309.3±32.7	7.38±0.03
60 min	46.4±1.7	327.3±21.4	7.38±0.02
90 min	46.1±2.6	320.1±20.2	7.37±0.31
HPCD + Hypoxia
Baseline	46.2±2.1	323.1±17.2	7.35±0.02
Hypoxia 1	46.6±2.7	*48.6±6.1	7.36±0.02
20 min	46.7±2.5	a265.7±47.1	7.36±0.02
40 min	46.1±2.6	316.6±17.8	7.37±0.02
60 min	46.2±1.9	316.6±24.6	7.36±0.02
90 min	46.3±2.1	321.5±23.9	7.36±0.03

Data are presented as Mean ± SD.

^ap<0.05 compared to CX717 group;

^bp<0.05 compared to CX717 + Hypoxia group;

^*,p<0.05 compared to baseline