Table 3.
Arterial blood gas values at 8-weeks post-injury. Blood gases were similar between the three treatment groups at baseline. Within each treatment group, values of each parameter were stable and not statistically different across the 90-minute experimental paradigm (with the exception of reduced PaO2 during hypoxia).
| 8 weeks post injury | PCO2 | PO2 | pH |
|---|---|---|---|
|
| |||
| CX717 | |||
| Baseline | 46.1±2.3 | 337.7±13.4 | 7.37±0.02 |
| 20 min | 46.1±2.9 | 330.5±10.6 | 7.36±0.02 |
| 40 min | 45.9±2.1 | 327.8±14.3 | 7.36±0.01 |
| 60 min | 46.5±2.5 | 327±11.1 | 7.36±0.01 |
| 90 min | 47.2±3.1 | 325.5±17.9 | 7.34±0.02 |
|
| |||
| CX717 + Hypoxia | |||
| Baseline | 46.1±1.5 | 330.9±9.3 | 7.37±0.02 |
| Hypoxia 1 | 45.6±1.7 | #50.7±7.6 | 7.37±0.02 |
| 20 min | 46.3±1.9 | a297.3±32.7 | 7.36±0.02 |
| 40 min | 46.3±1.5 | 319.4±12.8 | 7.35±0.02 |
| 60 min | 46.7±1.6 | 324±10.3 | #7.36±0.01 |
| 90 min | 46.2±1.7 | 321.6±7.8 | 7.35±0.02 |
|
| |||
| HPCD + Hypoxia | |||
| Baseline | 45.6±2.1 | 336.1±31.7 | 7.37±0.02 |
| Hypoxia 1 | 46.3±2.8 | #49.1±7.4 | 7.37±0.03 |
| 20 min | 45.9±1.7 | a281±38.7 | 7.36±0.02 |
| 40 min | 45.4±2.1 | 327.3±25.8 | 7.36±0.03 |
| 60 min | 46.1±2.6 | 331.3±29.7 | #7.36±0.03 |
| 90 min | 46.2±1.2 | 329.5±32.2 | 7.35±0.02 |
a
p<0.05 compared to CX717 group.
#
p<0.05 compared to the baseline value.
Data are presented as Mean ± SD.