Table 1.
Clinical characteristics of 5–2-1-positive and 5–2-1-negative patients
| All patients (n = 4714)a | 5–2-1 positive (n = 1546)a | 5–2-1 negative (n = 3168)a | P-value | |
|---|---|---|---|---|
| Patient age | ||||
| Mean (SD) | 69.3 (10.6) | 71.7 (10.4) | 68.2 (10.5) | < 0.0001 |
| ≥65 years, n (%) | 3309 (70.2) | 1231 (79.6) | 2078 (65.6) | < 0.0001 |
| Gender, n (%) | ||||
| Male | 2866 (60.8) | 964 (62.4) | 1902 (60.0) | 0.1274 |
| Charlson Comorbidity Index, mean (SD) | 0.4 (1.0) | 0.6 (1.2) | 0.3 (0.9) | < 0.0001 |
| Charlson Comorbidity Index, n (%) | ||||
| None (score 0) | 3765 (79.9) | 1108 (71.7) | 2657 (83.9) | < 0.0001 |
| Mild (score 1–2) | 787 (16.7) | 357 (23.1) | 430 (13.6) | |
| Moderate (score 3–4) | 120 (2.5) | 62 (4.0) | 58 (1.8) | |
| Severe (score 5+) | 42 (0.9) | 19 (1.2) | 23 (0.7) | |
| Time since PD diagnosis (years), mean (SD) | 4.3 (4.4) (n = 3712) | 7.2 (5.1) (n = 1162) | 3.0 (3.2) (n = 2550) | < 0.0001 |
| Physician judgment of PD stage, n (%) | ||||
| Non-advanced | 4012 (85.1) | 994 (64.3) | 3018 (95.3) | < 0.0001 |
| Advanced | 702 (14.9) | 552 (35.7) | 150 (4.7) | |
| Hoehn and Yahr stage, n (%) | ||||
| 1 | 1593 (33.8) | 1579 (39.4) | 14 (2.0) | < 0.0001 |
| 2 | 1545 (32.8) | 1492 (37.2) | 53 (7.5) | |
| 3 | 932 (19.8) | 778 (19.4) | 154 (21.9) | |
| 4 | 457 (9.7) | 147 (3.7) | 310 (44.2) | |
| 5 | 187 (4.0) | 16 (0.4) | 171 (24.4) | |
PD Parkinson’s disease, SD Standard deviation
aPatient number unless otherwise stated