Table 4.

sRAGE in different subtypes of emphysema

	No Emphysema (LAA below − 950HU < 6%)	Emphysema (LAA below -950HU $\ge$ 6%)
		Homogeneous	Heterogeneous
		No dominance − 10% < HD < 10%	Upper HD > 10%	Lower HD <  − 10%
Number	315	125	45	9
Presence COPD	49%1	86%2a	98%	100%
FEV1%pred	84.7% (20.0)1	63.1% (26.5)2a	56.9% (24.3)3	36.6% (10.3)
%LAA below -950HU	1.97 (1.65)1	13.86 (7.65)2c	23.38 (9.65)	29.19 (11.16)
Centrilobular	1 (0–4)1	3 (0–5) 2c	4 (3–5)3	4 (2–5)
Paraseptal	0 (0–2)1	0 (0–2)2a	1 (0–2)	0 (0–2)
sRAGE	2.22 (1.02)1	1.89 (0.75)2b	1.53 (0.73)	1.57 (0.45)

Data given in number, percentage, mean (standard deviation), or median (range). HD: heterogeneity difference (Upper–Lower Lobes %LAA below -950HU)

¹p < 0.0001 vs emphysema

^2ap < 0.05 vs heterogeneous emphysema

^2bp < 0.01 vs heterogeneous emphysema

^2cp < 0.0001 vs heterogeneous emphysema

³p < 0.05 vs lower lobe heterogeneous emphysema