TABLE 1.
Clinical data for 343 patients with nosocomial candidiasis
| Characteristic | No. (%) of patients |
|---|---|
| Sites of isolation | |
| Blood | 249 (73) |
| Sterile body fluids | 55 (16) |
| Catheter | 17 (5) |
| Tissue | 10 (3) |
| Underlying conditions | |
| Malignant disease | 96 (28) |
| Diabetes | 24 (7) |
| Transplantation | 20 (6) |
| Renal insufficiency | 20 (6) |
| Burn | 10 (3) |
| Trauma | 6 (2) |
| Human immunodeficiency virus infection | 6 (2) |
| Prematurity | 5 (2) |
| Predisposing factors | |
| Antibacterial therapy | 232 (68) |
| Central venous catheter | 207 (60) |
| Stay in intensive care unit | 155 (45) |
| Major surgery | 139 (41) |
| Parenteral nutrition | 138 (40) |
| Steroid therapy | 67 (20) |
| Neutropenia | 43 (13) |
| Central venous catheter | |
| Present | 207 (60) |
| Withdrawn | 175 (85) |
| Cultured (no. positive for yeast) | 85 (49) |
| Mortality | 130 (38) |
| Antifungal treatments (prediagnosis) | |
| Fluconazole | 32 (9) |
| Itraconazole | 4 (1) |
| Amphotericin B | 9 (3) |
| Antifungal treatments (postdiagnosis) | |
| Fluconazole | 210 (61) |
| Itraconazole | 7 (2) |
| Amphotericin B | 152 (44) |