Table 3.

Prothrombin complex concentrate brand and first dose

Study, Year	PCC3 brand	PCC4 brand *	Dose PCC3 (u/kg)	Dose PCC4 (u/kg)	Dose PCC3 (units)	Dose PCC4 (units)
Al-Majzoub et al., 2016 [20]	Profilnine® SD	KCentra®	25.5 (4.3)	27.9 (6.9)	NR	NR
DeAngelo et al., 2018 [22]	Profilnine® SD	KCentra®	25 [23–27]	23 [20–27]	2080 [1940–2500]*	1620 [1301–2213]*
Fischer et al., 2018 [24]	Profilnine® SD	KCentra®	26 [20–41]	25 [23–29]	2000 [1500–3248]	2088 [1665–2500]
Holt et al., 2018 [25]	NR	NR	24.6 (9.3)	36.3 (12.8)	NR	NR
Jones et al., 2016 [27]	Bebulin® VH	KCentra®	30.6 [28.2–32.3]	26.3 [24.7–34.3]	2454 [2228–3045]	2500 [2000–2852]
Kuroski et al., 2017 [28]	Bebulin® VH	KCentra®	28.9 (22.5–40.1), median (range)	25 (12–50)	NR	NR
Mangram et al., 2016 [30]	Bebulin® VH	KCentra®	29 (9)	26 (6)	NR	NR
Margraf et al., 2020 [31]	Profilnine® SD	KCentra®	21.5 [20.4–25.9]	29.3 [25.9–37.3]	2000 [1530–2500]	2595 [1880–3307]
Mohan et al., 2018 [32]	Bebulin® VH	KCentra®	40.99 (18), median (40.04)	32.22 (11.07), median (27.35)	3073 (1654)	2472 (930)
Voils et al., 2015 [33]	Profilnine® SD	KCentra®	28 [25–31]	27 [24–31]	2250 [1980–2970]	2250 [1788–2940]
Cang et al., 2014 [21]	NR	NR	NR	NR	NR	NR
Di Napoli et al., 2014 [23]	NR	NR	NR	NR	NR	NR
Kotsianas et al., 2015 [26]	NR	NR	NR	NR	NR	NR
Peck et al., 2016 [29]	NR	NR	NR	NR	NR	NR
Wagner et al., 2019 [34]	NR	NR	NR	NR	NR	NR
		* All US studies are assumed to have used Kcentra®				*First dose

INR international normalized ratio, NR not reported, PCC prothrombin complex concentrate, PCC3 3 factor PCC, PCC4 4 factor PCC