Table 5.

Timing of PCC administration

Study, Year	Time between initial INR and PCC dose PCC3	Time between initial INR and PCC dose PCC4	Time between PCC and second INR PCC3	Time between PCC dose and second INR PCC4
Al-Majzoub et al., 2016 [20]	NR	NR	5.0 (7.4) hours	3.7 (4) hours
DeAngelo et al., 2018 [22]	NR	NR	NR (88%)	NR (97%)
Fischer et al., 2018 [24]	NR	NR	NR	NR
Holt et al., 2018 [25]	NR	NR	3.8 (0.12) hours	3.3 (0.10) hours
Jones et al., 2016 [27]	NR	NR	48:59 [31:00–91:00] min:sec	23:40 [15:33–90:00] min:sec
Kuroski et al., 2017 [28]	37.9 (28.3) minutes	42.7 (27) minutes	191 (195) minutes	169 (230) minutes
Mangram et al., 2016 [30]	NR	NR	3 [0.6–16.5] hours	4.2 [0.6–18.9] hours
Margraf et al., 2020 [31]	78 [56.0–113.0] minutes	73 [40.0–108.5] minutes	93 [46.0–228.0] minutes	226 [156.5–368.5] minutes
Mohan et al., 2018 [32]	NR	NR	3 h (both groups)	3 h (both groups)
Voils et al., 2015 [33]	NR	NR	NR	NR
Cang et al., 2014 [21]	NR	NR	NR	NR
Di Napoli et al., 2014 [23]	NR	NR	NR	NR
Kotsianas et al., 2015 [26]	NR	NR	217 (247) minutes	208 (187) minutes
Peck et al., 2016 [29]	NR	NR	NR	NR
Wagner et al., 2019 [34]	NR	NR	NR	NR

INR international normalized ratio, NR not reported, PCC prothrombin complex concentrate, PCC3 3 factor PCC, PCC4 4 factor PCC