Table 6.

Patients stratified by bleed type

Study, Year	ICH PCC3	ICH PCC4	GIB PCC3	GIB PCC4	Other PCC3	Other PCC4	Not listed PCC3	Not listed PCC4
Al-Majzoub et al., 2016 [20]	26 (74.3%)	12 (66.7%)	7 (20%)	2 (11.1%)	2 (5.1%)	3 (16.7%)	NR	NR
DeAngelo et al., 2018 [22]	21 (61.8%)	10 (76.9%)	0 (0%)	2 (15.4%)	2 (5.9%)	1 (7.7%)	Thoracic 2 (5.9%), genitourinary GU 1 (2.9%), intraabdominal and retroperitoneal 8 (23.5%)	0 (0%)
Fischer et al., 2018 [24]	100%	100%	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Holt et al., 2018 [25]	48 (62%)	23 (40%)	5 (7%)	14 (24%)	13 (16%)	4 (7%)	Chest Bleeds = 4 (6%) Multiple = 7 (9%) Missing = 0	Chest Bleeds PCC4 = 0 Multiple = 15 (25%) Missing = 1 (2%)
Jones et al., 2016 [27]	80 (95.2%)	40 (62.5%)	2 (2.4%)	11 (17.2%)	2 (2.4%)	13 (20.3%)	NR	NR
Kuroski et al., 2017 [28]	48 (70.6%)	54 (78.3%)	4 (5.9%)	2 (2.9%)	12 (17.6%)	10 (14.5%)	Retroperitoneal: 2 (2.9%), Emergent Surgery: 2 (2.9%)	Retroperitoneal: 2 (2.9%), Emergent Surgery: 1 (1.4%)
Mangram et al., 2016 [30]*	NR	NR	NR	NR	NR	NR	NR	NR
Margraf et al., 2020 [31]	31 (54.4%)	19 (82.6%)	10 (17.5%)	2 (8.7%)	16 (28.1%)	2 (8.7%)	NR	NR
Mohan et al., 2018 [32]	45 (35%) (both groups)	45 (35%) (both groups)	33 (26%) (both groups)	33 (26%) (both groups)	29 (23%) (both groups)	29 (23%) (both groups)	Periprocedural 21 (16%) (both groups)	Periprocedural 21 (16%) (both groups)
Voils et al., 2015 [33]	65 (60%)	34 (61%)	7 (6%)	10 (18%)	6 (6%)	0 (0%)	IA/thoracic 12 (11%)	IA/thoracic 8 (14%)
Cang et al., 2014 [21]	NR	NR	NR	NR	NR	NR	NR	NR
Di Napoli et al., 2014 [23]	51 (100%)	18 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	NR
Kotsianas et al., 2015 [26]	100%	100%	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Peck et al., 2016 [29]	100%	100%	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Wagner et al., 2019 [34]	62%	50%	NR	NR	NR	NR	NR	NR

GIB gastrointestinal bleeding, ICH intracerebral hemorrhage, INR international normalized ratio, NR not reported, PCC prothrombin complex concentrate, PCC3 3 factor PCC, PCC4 4 factor PCC