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. 2022 Jan 10;8:762198. doi: 10.3389/fmed.2021.762198

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Copyright © 2022 Watanabe, Takasu, Teratake, Sakamoto, Ikeda, Kotani, Kitamura, Ohmori, Teratani, Honda, Hatano, Mayer, Schneider and Oda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mortality and morbidity of severe sepsis in genotype categories of thrombomodulin gene (THBD) single nucleotide polymorphisms (SNPs) rs2239562. (A) The Y-axis of the graph shows the mortality of severe sepsis in the SNPs that is in the promoter region of THBD (−1920^*C/G; rs2239562). The patients with the CC genotype of rs2239562 were significantly associated with worse outcome of severe sepsis than the CG + GG genotype of the SNP in the discovery cohort (P = 0.033). The trend was maintained in the validation cohort (P = 0.249), and the association was strengthened in the combined cohort (P = 0.028). (B) The Y-axis of the graph shows the genotypic distributions of the SNP that is in the promoter region of THBD (−1920^*C/G; rs2239562) in the patients with severe sepsis and without any evidence of sepsis (non-sepsis). The percentage of patients with the CC genotype of rs2239562 was significantly higher in the SS group than those in the non-sepsis group (P = 0.017). The P values for the SNP were evaluated with the chi-square test on the dominant model analysis with the correlation/trend test.