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. 2022 Jan 24;19:9. doi: 10.1186/s12989-021-00446-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The average changes (exposure order corrected) in a PNIF, and b PEF (L/min) during the exposures compared to the measurement before exposure. The change in PNIF and PEF from before exposure (ΔPNIF, ΔPEF) are estimated from linear mixed model after adjusting for exposure order. The measurements for all exposures are made at exactly the same time points (i.e., before exposures and at 55, 115, and 175 min into the exposure). The visible shift on the graph between exposures was applied to clearly show the values. The error bars represent the 95% confidence interval (CI)