Table 2.

Multivariable-adjusted hazard ratios for liver-related and all-cause mortality associated with alcohol intake by alanine aminotransferase (ALT) level status

Alcohol intake	Alanine aminotransferasea		p for interaction
	Normal HR (95% CI)	Elevated HR (95% CI)
Liver-related mortality			< 0.01
None	Reference	Reference
Light	0.73 (0.51, 1.05)	1.57 (1.08, 2.28)
Moderate	1.06 (0.73, 1.52)	2.09 (1.46, 2.99)
All-cause mortality
None	Reference	Reference	< 0.01
Light	0.72 (0.66, 0.77)	0.93 (0.81, 1.08)
Moderate	0.89 (0.82, 0.97)	1.31 (1.14, 1.50)

HRs and 95% CIs were obtained from proportional hazards models with age as time scale and adjusted for sex, body mass index, Charlson comorbidity index, diabetes, hypertension, hyperlipidemia, smoking status (never, ever or unknown), residential area (metropolitan, rural, and unknown), and income percentile (≤30th, >30th–≤70th, >70th, and unknown)

Abbreviation: HR, hazard ratio; CI, confidence interval

^aNormal: < 34 U/L for men and < 25 U/L for women; elevated: ≥34 U/L for men and ≥25 U/L for women