Table 3.
Multivariable-adjusted hazard ratios for liver-related and all-cause mortality associated with elevated alanine aminotransferase (ALT) levels by alcohol intake status
| Alcohol intake | Alanine aminotransferasea | p for interaction | |
|---|---|---|---|
| Normal HR (95% CI) |
Elevated HR (95% CI) |
||
| Liver-related mortality | < 0.01 | ||
| None | Reference | 2.84 (2.12, 3.80) | |
| Light | Reference | 6.10 (4.03, 9.24) | |
| Moderate | Reference | 5.63 (3.79, 8.34) | |
| All-cause mortality | < 0.01 | ||
| None | Reference | 0.97 (0.90, 1.04) | |
| Light | Reference | 1.26 (1.10, 1.45) | |
| Moderate | Reference | 1.41 (1.24, 1.61) | |
HRs and 95% CIs were obtained from proportional hazards models with age as time scale and adjusted for sex, body mass index, Charlson comorbidity index, diabetes, hypertension, hyperlipidemia, smoking status (never, ever or unknown), residential area (metropolitan, rural and unknown) and income percentile (≤30th, >30th–≤70th, >70th, and unknown)
Abbreviation: HR, hazard ratio; CI, confidence interval
aNormal: < 34 U/L for men and <25 U/L for women; elevated: ≥34 U/L for men and ≥25 U/L for women