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. 2022 Jan 24;41:33. doi: 10.1186/s13046-021-02230-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — High levels of RPS27a correlate with LUAD progression and poorer prognosis. A, B Comparison of RPS27a mRNA expression between normal lung tissues and tumor tissues with LUAD from TCGA datasets. *p < 0.05, **p < 0.01 were calculated with ANOVA. C The expression of RPS27a mRNA in LUAD types at different stages (http://gepia.cancer-pku.cn/). D, E Kaplan-Meier curves estimating overall survival (D) and disease-free survival (E) in patients with low and high expression levels of RPS27a mRNA in LUAD from the TCGA datasets. Log-rank test, p < 0.001. F The survival in patients with low and high expression levels of RPS27a mRNA in LUAD from GEO datasets. G-I The correlation analysis of RPS27a mRNA expression between other genes in patients with LUAD from TCGA datasets using Pearson’s correlation coefficient. The expression of mRNA was converted to log value and the scatter plot was drawn by the Ggplot-R software LUAD, lung adenocarcinoma