Table 2.
Clinical trials of IN COVID-19 vaccines.
| Type | Vaccine | Developer/manufacturer | Nasal delivery device | Phase | Status | Enrollment | Clinical trial No. | Route |
|---|---|---|---|---|---|---|---|---|
| Ad-vectored vaccine | Ad5-nCoV | CanSino/Beijing Institute of Biotechnology | Aerogen Ultra Device | I | Active, not recruiting | 149 | NCT04552366 | IN, IM or IN+IM |
| I/Ⅱ | Recruiting | 840 | NCT04840992 | IM or IN | ||||
| ChAdOx1 | AstraZeneca/University of Oxford | MAD Nasal™ Intranasal Mucosal Atomization Device | I | Enrolling by invitation | 54 | NCT04816019 | IN | |
| BBV154 | Bharat Biotech International Limited | N/A | I | Active, not recruiting | 175 | NCT04751682 | IN | |
| SC-Ad6–1 | Tetherex Pharmaceuticals Corporation | N/A | I | Recruiting | 80 | NCT04839042 | IM or IN | |
| AdCOVID | Altimmune, Inc. | Pipette droppers | I | Not processing | 180 | NCT04679909 | IN | |
| NDV-vectored vaccine | AVX/COVID-12-HEXAPRO | Laboratorio Avi-Mex, S.A. de C.V. | An automatic syringe (Prima mist sprayer) | I | Recruiting | 90 | NCT04871737 | IN, IM or IN+IM |
| LAIV-vectored vaccine | DelNS1–2019-nCoV-RBD-OPT1 | University of Hong Kong, Xiamen University and Beijing Wantai Biological Pharmacy | Spray devices | I | Complete | 60 | ChiCTR2000037782 | IN |
| Ⅱ | Complete | 720 | ChiCTR2000039715 | IN | ||||
| III | – | 40,000 | ChiCTR2100051391 | IN | ||||
| PIV5-vectored vaccine | CVXGA1 | CyanVac LLC | Spray devices | I | Not recruiting | 80 | NCT04954287 | IN |
| RSV-vectored vaccine | MV-014–212 | Meissa Vaccines, Inc. | Droppers or spray devices | I | Recruiting | 130 | NCT04798001 | IN |
| Protein subunit vaccine | CIGB-669 | CIGB | Syringe-based spray devices | I/Ⅱ | Pending | 88 | RPCEC00000345 | IN alone or IN + IM |
| Razi Cov Pars | Razi Vaccine and Serum Research Institute | Spray devices | I | Complete | 133 | IRCT20201214049709N1 | IM + IN | |
| Ⅱ | Complete | 500 | IRCT20201214049709N2 | IM + IN | ||||
| III | – | 41,128 | IRCT20210206050259N3 | IM + IN | ||||
| Live attenuated vaccine | COVI-VAC | Codagenix, Inc. | Droppers | I | Active, not recruiting | 48 | NCT04619628 | IN |
NDV: Newcastle disease virus; LAIV: live attenuated influenza virus; PIV: parainfluenza virus; RSV: respiratory syncytial virus; N/A: Not available. Data from https://clinicaltrials.gov/, https://www.chictr.org.cn/index.aspx and https://covid-19.cochrane.org/.