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. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: DNA Repair (Amst). 2021 Jun 19;105:103161. doi: 10.1016/j.dnarep.2021.103161

Figure 1. MMR must target the daughter DNA strand.

Figure 1.

Hypothetical processing of a T:G mispair arising due to a DNA replication error can lead to multiple genetic outcomes. In MMR, excision and resynthesis target the daughter strand (gray), which eliminates the mispair prior to DNA replication and no mutant progeny are produced. If the mispair is unrepaired, then DNA replication will generate one wild-type progeny and one mutant progeny. If the parental strand (black) were to be targeted by excision and resynthesis, then the mispair would be converted into a mutation and propagated in all subsequent rounds of DNA replication.